Mikel Arteta's side finished fifth last season, but they are in pole position to land their first Premier League title since 2004 after winning 15 of their 18 league games this term.
Speaking ahead of Sunday's clash, Dutch manager Erik Ten Hag said on Friday, "It is obvious they are in a really good run and I think they deserve the position where they are now.
"It's a really good structure, how they play. There's a really good mentality, a winning attitude in that team. That's why they are top of the list.
"So, they are in a great run but it is up to us to beat that run and we will do everything to do that."
United are the only team to beat Arsenal in the league this season, with Ten Hag's men enjoying a 3-1 victory at Old Trafford in September.
Asked if he was surprised to see Arsenal still leading the table, Ten Hag said: "No. In the moment we played them, you could already see that the manager with his coaching staff was for a long time already working on that team.
"You see really good structures in the team and I think they even improved during the first half of the season."
Although third-placed United are eight points behind Arsenal, who also have a game in hand on both Manchester clubs, Ten Hag's side head to north London on a 10-match unbeaten run.
United had won nine in a row in all competitions before Michael Olise's stoppage-time free-kick forced them to settle for a frustrating 1-1 draw at Crystal Palace.
A United victory on Sunday would rekindle their hopes of catching Arsenal and Ten Hag is confident they can inflict a second dose of misery on the Gunners this season.
"We know what to do. We have to be really good. We need a really good performance," he said.
"But if we do, I think we have a good chance also to get out of that performance a good result."
One issue for Ten Hag to resolve is how to replace Casemiro after the Brazil midfielder's booking at Palace triggered a suspension that rules him out of the Arsenal game.
Casemiro only featured as a late substitute in the September win against Arsenal and Ten Hag said: "We beat last time Arsenal without Casemiro.
"We have an idea of how to do it (again), yeah."