Mikel Arteta's side dropped points for only the second time this season as Stuart Armstrong's equaliser forced the Premier League leaders to settle for a 1-1 draw against Southampton on Sunday.
Mikel Arteta's side went in front through Granit Xhaka's first-half strike at St Mary's.
But Armstrong levelled after the interval as Arsenal paid the price for failing to convert several chances to increase their advantage.
It was a rare slip from the Gunners, who had won nine of their 10 previous league games this season, with their only defeat coming at Manchester United.
The end of Arsenal's eight-game winning run in all competitions leaves them two points clear of second-placed Manchester City with both having played 11 games.
While Arteta will be frustrated that Arsenal squandered the lead given to them by Swiss midfielder Xhaka, it is a tribute to his team's unexpected rise this season that failing to take maximum points ranks as a disappointment.
Arsenal have 28 points after 11 matches, their best ever total at this stage of a Premier League season.
But Arteta said: "We had three or four good opportunities and should have scored more. We needed two or three goals, but only scored one.
"It's very disappointing. We created enough chances but couldn't put the ball away.
"It's a lesson because we wanted to win again. They put us under more pressure through direct play in the second half, and we were struggling."