Nigeria forward Kelechi Iheanacho on target as Leicester City halt streak of losses to defeat fourth-tier side Gillingham in the FA Cup to progress into the fourth round on Saturday.
Leicester manager Brendan Rodgers, who led his side to the trophy two years ago, made multiple changes after his team's third straight Premier League defeat this week but retained veteran forward Jamie Vardy for the match against Gillingham, who are rock bottom of England's Football League.
Vardy was the provider as Kelechi Iheanacho scored the only goal of the game in the 56th minute.
Palace took the lead against Premier League basement club Southampton through Odsonne Edouard.
But Saints levelled in the 37th minute after some poor defending from the hosts. James Ward-Prowse sent what looked to be an innocuous free-kick into the area but Joel Ward mistimed his effort to head clear.
The ball took a bounce inside the box before evading goalkeeper Vicente Guaita, who moved in the right direction but could not stop it from going into the net.
Southampton took the lead for the first time midway through the second half.
Guaita was attempting to make a routine clearance from outside the area when Adam Armstrong rushed in, stole the ball from the Spaniard and had plenty of time to find the empty net.
Preston came from behind to beat Huddersfield 3-1 while Reading beat Watford 2-0.
Liverpool take on Wolves in the standout match of the day later on Saturday, with Manchester City hosting Chelsea on Sunday.
Manchester United beat Everton 3-1 on Friday in another all-Premier League clash.
Forest Green's tie against Birmingham was postponed on Saturday due to a waterlogged pitch.