Gennaro Gattuso has been a coach to four different clubs in the last three years.
The decision comes after Valencia's 1-0 defeat to Valladolid on Sunday, leaving them 14th in the LaLiga standings and just one point above the relegation zone.
Gattuso, a former defensive midfielder who played 73 times for Italy, has had a successful career as a head coach.
He managed AC Milan for two seasons from 2015 to 2017 and took home the Coppa Italia trophy in 2020 during his time at Napoli. However, Gattuso's tenure at Valencia was not without challenges, as he reportedly had been frustrated with the club's lack of transfer activity.
The club confirmed that long-time coach Voro, who has served as a caretaker or interim boss at Valencia on six occasions, will be taking over when the squad resumes training on Tuesday. This will be Voro's seventh time filling in as interim coach for the club.
Gattuso's departure from Valencia marks the end of his brief stint at the club. He previously agreed to join Fiorentina in the summer of 2021 but quit before starting his contract due to a dispute over the club's transfer policy. Despite the challenges, Gattuso leaves behind a legacy of success and his next move will be closely watched by fans and commentators alike.