Runner-up Barcelona will host Rayo Vallecano the same weekend.
With the World Cup in Qatar scheduled to be played for the first time in the middle of the European domestic season, the LaLiga campaign will not end until next June.
The World Cup is due to start on 21 November and LaLiga will resume on 31 December, two weeks after the final
The Clasico meetings between Real Madrid and Barcelona will be over the weekend of 16 October at Santiago Bernabeu and the weekend of 19 March at Camp Nou.
The Spanish Supercup in Saudi Arabia will take place between January and the Copa del Rey final on 6 May.