A week after they led away to Paris Saint-Germain until the 74th minute only to lose, Lille went ahead when Tiago Djalo struck in the 28th minute, slotting home from a free-kick by Renato Sanches.
But they allowed a late equaliser from Azzedine Ounahi who calmly finished from a far-post cross from Sofiane Boufal.
One of last season's stars, Burak Yilmaz summed up Lille's struggles in the fifth minute of added time. Unmarked on the penalty spot he fell over as he attempted to shoot.
Lille, who have not won in the league since they beat Marseille on 3 October, remained in 12th. They are 15 points behind runaway leaders PSG who visit Bordeaux in Saturday's late game.
In the remaining seconds, Lille substitute Amadou Onana was red-carded for a wild tackle.
Angers climbed to seventh.
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