Lionel Messi, however, will not be on show in round 16 as he is still at home, celebrating Argentina's success in the World Cup final in Qatar.
The club, though, has been buoyed by reports last week that the 35-year-old Messi is set to sign a one-year extension to his contract which expires in the summer.
Mbappe, who scored a hat-trick in the World Cup final but still ended up on the losing side as France flunked the penalty shoot-out, reported back to training on Wednesday with Achraf Hakimi, one of the stand-outs in Morocco's run to the semifinals.
Mbappe, Messi and Hakimi were just three of the 14 Ligue 1 players – from eight different clubs – who reached the semifinals in Qatar.
Neymar, whose Brazil crashed out to Croatia in the quarterfinals, was back on Thursday with compatriot Marquinhos, with both expected to play a role in Wednesday's game at the Parc des Princes.
PSG are currently five points clear of second-placed Lens who they meet in Flanders on Sunday.
Lens, meanwhile, will look to keep up the pressure on PSG going into that game when they head down to Nice on Thursday.
Third-placed Rennes have Croatia's Lovro Majer and on-loan Wales defender Joe Rodon back from action in Qatar as they head to Reims on Thursday.
"For me, it's a second season that's starting up again, with the same uncertainties, the same unknowns before a first league match of the season," said Rennes manager Bruno Genesio. "We'll see which teams have best managed this."
Marseille, who are just one point behind in fourth, host a Toulouse side that is bumping around in mid-table.