Cavani - Marca.com
United are aiming to get to a final under Ole Gunnar Solskjaer at the fifth time of asking after four semi-final defeats in the past two seasons.
But only a second leg collapse will prevent them from facing Villarreal or Arsenal in Gdansk on May 26 after a stunning second-half performance.
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The home side trailed at the break as Lorenzo Pellegrini's penalty and Edin Dzeko's tap-in cancelled out Fernandes's early opener.
But the Italians lost three players to injury before the break and United took full advantage.
Two predatory finishes from Cavani turned the tie around before Fernandes also fired home from the spot.
Paul Pogba and Mason Greenwood rounded off the scoring as United became the first team to score six goals in a European semifinal since Real Madrid in 1964.
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"Very pleased with the response," said Solskjaer. "Second half we were very good."
"We know we've got creative players, players who can create big chances, score goals, it's about getting them in the positions," added Solskjaer.
"Marcus (Rashford), Bruno, Paul, Edinson are all capable. The difference today is we took most of our chances."
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