The France international sustained an anterior cruciate ligament injury during the team's hard-fought 3-2 win over Elche in LaLiga last Friday, leaving Betis reeling from the loss of their star player.
Fekir's absence will be felt heavily by the team, as they fight to secure a top-four finish in LaLiga and prepare to face Premier League giants Manchester United in the Europa League.
The loss of such a creative force in midfield could not come at a worse time for Betis, who will be looking to overcome an in-form United side to progress further in the tournament.
Real Betis released a statement confirming the injury, stating that Fekir would require surgery to address the issue.
The news is a massive blow to the team, who are hoping to qualify for the Champions League for the first time since the 2005-06 season.
While Betis will be without Fekir for the remainder of the season, there is some good news on the horizon as their other key midfielder, Sergio Canales is set to return from a muscular injury.
The Spanish international is expected to be fit for their clash against Manchester United at Old Trafford on March 9, providing a glimmer of hope for the team's chances in the Europa League.