Sampdoria's Jeison Murillo received a second yellow card and was sent off in the 52nd minute after a late tackle on Tammy Abraham, reducing the team to ten men. Despite the disadvantage, Sampdoria's goalkeeper, Nicola Ravaglia, made some impressive saves to keep the game goalless in the first half.
Roma took the lead in the 57th minute when Wijnaldum scored his second league goal of the season with a straightforward header. Dybala then scored a penalty in the 89th minute after Ravaglia fouled Wijnaldum, and El Shaarawy sealed the victory for the hosts with a goal in the fourth minute of stoppage time.
With this win, Roma moved up to the fourth position in Serie A, level on points with third-placed Inter Milan. AC Milan, who are in fifth place with two points behind Roma, will play against league leaders Napoli later on Sunday.
On the other hand, Sampdoria's defeat left the Genoa club second-bottom in the league table, with just 15 points from 28 matches, and 10 points away from safety.