Son Heung-min and James Maddison were on target to help Tottenham return to the top of the Premier League.
Spurs comfortably saw off Fulham 2-0 in Monday night's London derby clash.
Captain Son curled in an excellent goal in the 36th minute after a poor pass from Calvin Bassey was cut out by Micky van de Ven.
Maddison then doubled the lead in the second half after another pass from Bassey was cut out and the England playmaker was teed up by Son to slot home confidently.
Joao Palhinha almost pulled one back for Fulham with a header from a corner but goalkeeper Guglielmo Vicario was alert to keep a clean sheet.
The win means unbeaten Tottenham lead the way in the Premier League with seven wins from their opening nine matches, two points above Manchester City and city rivals Arsenal.
Ange Postecoglou’s side will have the chance to go five points clear when they travel to Crystal Palace on Friday night, while Marco Silva's side will take a trip to Brighton on Sunday.