Antoine Griezmann, Dayot Upamecano, Olivier Giroud as well as an own goal from the visitors' goalkeeper Dominik Livakovic secured a repeat result from Russia two years ago as France cruised past Croatia in a comeback at France.
Didier Deschamps's World Cup winners are second on goal difference in Group A behind Portugal who beat Sweden 2-0 as Cristiano Ronaldo crossed the 100-goal mark for his country.
Deschamps made seven changes from Saturday's win in Solna with Wissam Ben Yedder and Anthony Martial leading the attack after Kylian Mbappe contracted Covid-19.
Former Liverpool center-back, Dejan Lovren opened the scoring for the visitors in a near-empty ground due to the coronavirus pandemic with a half-volleyed effort inside the hosts' box after a quarter of an hour of play.
Griezmann, who missed a penalty in the weekend's victory, equalized with two minutes of the first half remaining by side-footing home Martial's low cross.
Manchester United's Martial was involved in the next les Bleus goal a minute into injury time.
Dominik Livakovic fumbled Martial's attempt into his goal after Ben Yedder's dangerous ball.
The sides were equal once again 10 minutes into the second half as Chelsea's Mateo Kovacic split the home side's defense in half with a tidy through ball.
Substitute Josip Brekalo held up possession well before sliding his effort past Hugo Lloris.
Camavinga's historic moment came 27 minutes from time as he substituted Chelsea's Kante, He became France youngest International in 96 years to play - aging just 17 years and 9 months. He is surpassed by Julien Verbrugghe - 16 years 10 months in 1906, Maurice Gastiger - 17 years and 4 months in 1914.
Camavinga can be called the youngest France International since 1915.
Deschamps's side claimed all three points with two goals in the final 25 minutes.
Upamecano claimed the third goal, and his first in international football, with a header from a Griezmann corner.
Chelsea's Giroud then converted a 77th-minute penalty for the fourth before France closed out the game.