Despite a close chance by Alessandro Bastoni, Porto's keeper Diogo Costa saved the header before the halftime break.
Porto were reduced to 10 men when midfielder Otavio was sent off after receiving a second yellow card for a challenge on Hakan Calhanoglu 12 minutes from time.
Lukaku 29, who has been injured and missed most of Inter's games this season came on for Edin Dzeko, headed against the post before scoring the rebound to secure the win.
The second leg will be played on March 14.
Oladimeji Balogun is a graduate of the University of Ilorin where he studied Microbiology, he is a w...
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